NIMG-05. DYNAMIC SUSCEPTIBILITY CONTRAST MRI IN THE EVALUATION OF BRAIN METASTASES: CURRENT PRACTICE REVIEW AND RATIONALE FOR STUDY OF BASELINE PERFUSION IMAGING PRIOR TO STEREOTACTIC RADIOSURGERY (STARBEAM-X)

Abstract Stereotactic radiosurgery (SRS) is an established focal treatment for brain metastases with high local control rates. An important side-effect of SRS the development radionecrosis. On conventional MR imaging, radionecrosis and tumour progression often have similar appearances, but contrasting management approaches. Perfusion imaging used in post-treatment setting order to help distinguish between two, image interpretation can be fraught challenges.Perfusion plays role baseline evaluation primary tumours a number studies concentrated on value perfusion metastases. Of parameters generated, relative cerebral blood volume most widely variable terms its clinical differentiating progression.Although it has been suggested that rCBV tends elevated active metastatic disease following radiosurgery, not treatment-related changes, literature available ratios provided context defining consistent.We provide overview MRI assessment introduces rationale STARBEAM-X study (Study using extra imaging), which will prospectively evaluate We present here results first three patients recruited feasibility phase this study. hope allow insight into vascular appearance from different sites, aid imaging.